Focal cortical dysplasia: Molecular disturbances and clinicopathological classification (Review)
نویسندگان
چکیده
منابع مشابه
Focal cortical dysplasia – review
Focal cortical dysplasia is a malformation of cortical development, which is the most common cause of medically refractory epilepsy in the pediatric population and the second/third most common etiology of medically intractable seizures in adults.Both genetic and acquired factors are involved in the pathogenesis of cortical dysplasia. Numerous classifications of the complex structural abnormalit...
متن کاملFocal Cortical Dysplasia.
Focal cortical dysplasias are common malformations of cerebral cortical development and are highly associated with medically intractable epilepsy. They have been classified into neuropathological subtypes (type Ia, Ib, IIa, IIb, and III) based on the severity of cytoarchitectural disruption--tangential or radial dispersion, or loss of laminar structure--and the presence of unique cells types su...
متن کاملCortical development and focal cortical dysplasia.
A brief survey of cortical development is presented, focusing on neuronal migration and its alterations. Corticogenesis is achieved through ordered temporospatial steps, via the formation of transient structures, and successive waves of cell proliferation and migration (followed by cell differentiation and maturation), and apoptotic cell death. The appearance of the proliferative ventricular zo...
متن کاملNew Classification of Focal Cortical Dysplasia: Application to Practical Diagnosis
BACKGROUND AND PURPOSE Malformation of cortical development (MCD) is a well-known cause of drug-resistant epilepsy and focal cortical dysplasia (FCD) is the most common neuropathological finding in surgical specimens from drug-resistant epilepsy patients. Palmini's classification proposed in 2004 is now widely used to categorize FCD. Recently, however, Blumcke et al. recommended a new system fo...
متن کاملFocal Cortical Dysplasia and Epilepsy Surgery
Focal cortical dysplasia (FCD) is the most commonly encountered developmental malformation that causes refractory epilepsy. With advances in neuroimaging techniques, in particular MRI, recent studies have revealed a higher prevalence of FCD than previously estimated and have improved the preoperative identification and classification of these abnormalities. However, MRI frequently does not show...
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ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2016
ISSN: 1107-3756,1791-244X
DOI: 10.3892/ijmm.2016.2760